Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models

Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models

Head and neck squamous cell carcinoma (HNSCC) is characterized by overexpression of the epidermal growth factor receptor (EGFR) where treatments targeting EGFR have met with limited clinical success. Elucidation of the key downstream-pathways that remain activated in the setting of EGFR blockade ma...

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Bibliographic Details
Main Authors: Andre Cassell, Maria L Freilino, Jessica Lee, Sharon Barr, Lin Wang, Mary C Panahandeh, Sufi M Thomas, Jennifer R Grandis
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612801126

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http://www.sciencedirect.com/science/article/pii/S1476558612801126

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