Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile

Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile

The thyroid hormone derivative 3-iodothyronamine (3-T1AM) exerts metabolic effects in vivo that contradict known effects of thyroid hormones. 3-T1AM acts as a trace amine-associated receptor 1 (TAAR1) agonist and activates Gs signaling in vitro. Interestingly, 3-T1AM-meditated in vivo effects persi...

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Bibliographic Details
Main Authors: Jessica Mühlhaus, Juliane Dinter, Daniela Nürnberg, Maren Rehders, Maren Depke, Janine Golchert, Georg Homuth, Chun-Xia Yi, Silke Morin, Josef Köhrle, Klaudia Brix, Matthias Tschöp, Gunnar Kleinau, Heike Biebermann
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:International Journal of Molecular Sciences
Subjects:
trace amine-associated receptor
TAAR8
3-T1AM
thyronamine
signaling pathways
basal activity
Online Access:http://www.mdpi.com/1422-0067/15/11/20638

Internet

http://www.mdpi.com/1422-0067/15/11/20638

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