Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells

Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells

Purpose: Doxorubicin is administrated as a single agent in first-line therapy of breast cancer to induce apoptosis in tumor cells. Bax, Bcl-xL, Caspase-8 and 9 proteins are involved in induction of apoptosis. The present study describes Bax, Bcl-xL gene expression and Caspase-8 and 9 protein levels...

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Bibliographic Details
Main Authors: Simin Sharifi, Jaleh Barar, Mohammad Saeid Hejazi, Nasser Samadi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2015-09-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
MCF-7
Apoptosis
Doxorubicin
Breast cancer
Bax /Bcl-xL
Caspase-9
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-351.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-351.pdf

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