Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribut...

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Bibliographic Details
Main Authors: Susann Björk, Elina A. Ojala, Tommy Nordström, Antti Ahola, Mikko Liljeström, Jari Hyttinen, Esko Kankuri, Eero Mervaala
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
optogenetics
human iPSC-derived cardiomyocytes
optical action potential
contractile motion
hERG
cardiac electrophysiology
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00884/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00884/full

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