Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.

Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.

Evidence link bacterial enterotoxins to apparent crypt-cell like cells (CCLCs), and Alpha Defensin 5 (DEFA5) expansion in the colonic mucosa of Crohn's colitis disease (CC) patients. These areas of ectopic ileal metaplasia, positive for Paneth cell (PC) markers are consistent with diagnosis of...

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Bibliographic Details
Main Authors: Tanu Rana, Olga Y Korolkova, Girish Rachakonda, Amanda D Williams, Alexander T Hawkins, Samuel D James, Amos M Sakwe, Nian Hui, Li Wang, Chang Yu, Jeffrey S Goodwin, Michael G Izban, Regina S Offodile, Mary K Washington, Billy R Ballard, Duane T Smoot, Xuan-Zheng Shi, Digna S Forbes, Anil Shanker, Amosy E M'Koma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0246393

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https://doi.org/10.1371/journal.pone.0246393

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