Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study
Purpose: To assess the efficacy and safety of docetaxel rechallenge in the salvage setting in metastatic castration-resistant prostate cancer (mCRPC) patients. Materials and Methods: Clinicopathologic data from patients treated with docetaxel rechallenge were collected from a single-center cancer re...
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Korean Urological Association
2020-11-01
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doaj-032931454c074bf69dd97883f9b61f7f2020-11-25T04:01:06ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2020-11-0161658859310.4111/icu.20200214Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center studySeonggyu Byeon 0Hyera Kim 1Jinchul Kim 2Minsuk Kwon 3Joon Young Hur 4Hwang Gyun Jeon 5Seong Soo Jeon 6Hyun Moo Lee 7Se Hoon Park 8Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Purpose: To assess the efficacy and safety of docetaxel rechallenge in the salvage setting in metastatic castration-resistant prostate cancer (mCRPC) patients. Materials and Methods: Clinicopathologic data from patients treated with docetaxel rechallenge were collected from a single-center cancer registry. Among 227 patients who received first-line docetaxel for mCRPC between January 2011 and June 2019, 23 undergo rechallenge docetaxel after failure to androgen receptor targeting agents and/or cabazitaxel treatment. Endpoints included radiologic progression-free survival (PFS), treatment duration, and prostate-specific antigen (PSA) response and safety. Results: Overall, 30%, 44%, 13%, and 13% of patients received docetaxel rechallenge as either the third, fourth, fifth, or sixth-line therapy, respectively, at a median of 23.6 months after stopping first-line docetaxel. With first-line docetaxel and rechallenge, median treatment duration was 6.4 and 3.3 months, respectively. With docetaxel rechallenge, PSA response was 35% (95% confidence interval [CI], 15% to 54%) and median PFS was 4.5 months (95% CI, 1.9 to 7.1 months). The median OS was 24.3 months (95% CI, 4.6 to 44.0 months). There were 7 severe adverse events (grade 3 or more) including anemia (8.7%), neutropenia, thrombocytopenia, leukopenia, diarrhea, and nausea (4.3% each). Conclusions: Docetaxel rechallenge showed meaningful anti-tumor activity with acceptable toxicity in heavily pretreated patients with mCRPC.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-588.pdfchemotherapydocetaxelprostate cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seonggyu Byeon Hyera Kim Jinchul Kim Minsuk Kwon Joon Young Hur Hwang Gyun Jeon Seong Soo Jeon Hyun Moo Lee Se Hoon Park |
spellingShingle |
Seonggyu Byeon Hyera Kim Jinchul Kim Minsuk Kwon Joon Young Hur Hwang Gyun Jeon Seong Soo Jeon Hyun Moo Lee Se Hoon Park Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study Investigative and Clinical Urology chemotherapy docetaxel prostate cancer |
author_facet |
Seonggyu Byeon Hyera Kim Jinchul Kim Minsuk Kwon Joon Young Hur Hwang Gyun Jeon Seong Soo Jeon Hyun Moo Lee Se Hoon Park |
author_sort |
Seonggyu Byeon |
title |
Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study |
title_short |
Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study |
title_full |
Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study |
title_fullStr |
Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study |
title_full_unstemmed |
Docetaxel rechallenge in metastatic castration-resistant prostate cancer: A retrospective, single-center study |
title_sort |
docetaxel rechallenge in metastatic castration-resistant prostate cancer: a retrospective, single-center study |
publisher |
Korean Urological Association |
series |
Investigative and Clinical Urology |
issn |
2466-0493 2466-054X |
publishDate |
2020-11-01 |
description |
Purpose: To assess the efficacy and safety of docetaxel rechallenge in the salvage setting in metastatic castration-resistant prostate cancer (mCRPC) patients. Materials and Methods: Clinicopathologic data from patients treated with docetaxel rechallenge were collected from a single-center cancer registry. Among 227 patients who received first-line docetaxel for mCRPC between January 2011 and June 2019, 23 undergo rechallenge docetaxel after failure to androgen receptor targeting agents and/or cabazitaxel treatment. Endpoints included radiologic progression-free survival (PFS), treatment duration, and prostate-specific antigen (PSA) response and safety. Results: Overall, 30%, 44%, 13%, and 13% of patients received docetaxel rechallenge as either the third, fourth, fifth, or sixth-line therapy, respectively, at a median of 23.6 months after stopping first-line docetaxel. With first-line docetaxel and rechallenge, median treatment duration was 6.4 and 3.3 months, respectively. With docetaxel rechallenge, PSA response was 35% (95% confidence interval [CI], 15% to 54%) and median PFS was 4.5 months (95% CI, 1.9 to 7.1 months). The median OS was 24.3 months (95% CI, 4.6 to 44.0 months). There were 7 severe adverse events (grade 3 or more) including anemia (8.7%), neutropenia, thrombocytopenia, leukopenia, diarrhea, and nausea (4.3% each). Conclusions: Docetaxel rechallenge showed meaningful anti-tumor activity with acceptable toxicity in heavily pretreated patients with mCRPC. |
topic |
chemotherapy docetaxel prostate cancer |
url |
https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-588.pdf |
work_keys_str_mv |
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