Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency

Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency

<p>Abstract</p> <p>Succinic semialdehyde dehydrogenase (SSADH; aldehyde dehydrogenase 5A1 [ALDH5A1]; locus 6p22) occupies a central position in central nervous system (CNS) neurotransmitter metabolism as one of two enzymes necessary for <it>γ</it>-aminobutyric acid (GAB...

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Bibliographic Details
Main Authors:	Malaspina Patrizia, Picklo Matthew J, Jakobs C, Snead O Carter, Gibson K Michael
Format:	Article
Language:	English
Published:	BMC 2009-01-01
Series:	Human Genomics
Subjects:	GABA GHB succinic semialdehyde dehydrogenase deficiency aldehyde dehydrogenase 5A1 chromosome 6p22 <it>Aldh5a1</it><sup>-/- </sup>mouse model alternative splicing AKR7A2 polymorphic variation quantitative traits
Online Access:	http://www.humgenomics.com/content/3/2/106

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