Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM
Objective: To study the effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with gestational diabetes mellitus (GDM). Methods: Patients with GDM who received insulin therapy between March 2013 and Ma...
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doaj-03682b9d16a44b07ac3408eb70f8c0a82020-11-24T23:29:44ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-05-012394851Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDMLiu Jie0Pharmacy Department, Zigong Maternal and Child Health-Care Hospital in Sichuan Province, Zigong City, Sichuan Province, 643000Objective: To study the effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with gestational diabetes mellitus (GDM). Methods: Patients with GDM who received insulin therapy between March 2013 and May 2016 were selected as the research subjects and randomly divided into multiple subcutaneous insulin injection (MSII) group and continuous subcutaneous insulin pump infusion (CSII) group. Before and after treatment, serum glucolipid metabolism as well as inflammation and oxidative stress inexes in placenta were determined respectively. Results: 2 weeks and 4 weeks after treatment, FBG, 1hPBG, 2hPBG, Chemerin, Vaspin and Visfatin levels of both groups of patients were significantly lower than those before treatment and FBG, 1hPBG, 2hPBG, Chemerin, Vaspin and Visfatin levels of CSII group were significantly lower than those of MSII group; after delivery, TNF-α, IL-6, ROS and AGEs levels in placenta of CSII group were significantly lower than those of MSII group. Conclusion: Continuous subcutaneous insulin infusion can more effectively improve the glucolipid metabolism and inhibit the inflammation and oxidative stress in placenta of patients with GDM than multiple subcutaneous insulin injection.http://www.hnykdxxb.com/PDF/201709/12.pdfGestational diabetes mellitusInsulin pumpAdipocytokineInflammationOxidative stress |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liu Jie |
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Liu Jie Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM Journal of Hainan Medical University Gestational diabetes mellitus Insulin pump Adipocytokine Inflammation Oxidative stress |
author_facet |
Liu Jie |
author_sort |
Liu Jie |
title |
Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM |
title_short |
Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM |
title_full |
Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM |
title_fullStr |
Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM |
title_full_unstemmed |
Effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with GDM |
title_sort |
effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with gdm |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-05-01 |
description |
Objective: To study the effect of continuous subcutaneous insulin pump infusion on glucolipid
metabolism as well as inflammation and oxidative stress in placenta of patients with gestational
diabetes mellitus (GDM). Methods: Patients with GDM who received insulin therapy between
March 2013 and May 2016 were selected as the research subjects and randomly divided into
multiple subcutaneous insulin injection (MSII) group and continuous subcutaneous insulin
pump infusion (CSII) group. Before and after treatment, serum glucolipid metabolism as well
as inflammation and oxidative stress inexes in placenta were determined respectively. Results:
2 weeks and 4 weeks after treatment, FBG, 1hPBG, 2hPBG, Chemerin, Vaspin and Visfatin
levels of both groups of patients were significantly lower than those before treatment and FBG,
1hPBG, 2hPBG, Chemerin, Vaspin and Visfatin levels of CSII group were significantly lower
than those of MSII group; after delivery, TNF-α, IL-6, ROS and AGEs levels in placenta
of CSII group were significantly lower than those of MSII group. Conclusion: Continuous
subcutaneous insulin infusion can more effectively improve the glucolipid metabolism and
inhibit the inflammation and oxidative stress in placenta of patients with GDM than multiple
subcutaneous insulin injection. |
topic |
Gestational diabetes mellitus Insulin pump Adipocytokine Inflammation Oxidative stress |
url |
http://www.hnykdxxb.com/PDF/201709/12.pdf |
work_keys_str_mv |
AT liujie effectofcontinuoussubcutaneousinsulinpumpinfusiononglucolipidmetabolismaswellasinflammationandoxidativestressinplacentaofpatientswithgdm |
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