Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis

Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis

Several studies have indicated that apoptotic pathways are responsible for the loss of motor neurons that constitute the hallmark of amyotrophic lateral sclerosis (ALS). In this study, we demonstrate that apoptosis induced by the expression of several mutant Cu,Zn superoxide dismutases (SOD1) typica...

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Bibliographic Details
Main Authors: Mauro Cozzolino, Alberto Ferri, Elisabetta Ferraro, Giuseppe Rotilio, Francesco Cecconi, Maria Teresa Carrì
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Neurobiology of Disease
Subjects:
Familial amyotrophic lateral sclerosis
Mitochondria
Neurodegeneration
Oxidative stress
Superoxide dismutase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001749

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http://www.sciencedirect.com/science/article/pii/S0969996105001749

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