Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour progression and therapy resistance. Through RNAi screening, we identified a novel EV uptake mechanism involving a trip...

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Bibliographic Details
Main Authors: Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C. de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H. W. Crommentuijn, Laurine E. Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H. van der Meulen-Muileman, Rogier M. Reijmers, Toin H. van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A. Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W. Peter Vandertop, David P. Noske, Victor W. van Beusechem, Jacco van Rheenen, D. Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Journal of Extracellular Vesicles
Subjects:
Extracellular vesicles
glioblastoma
Chemokine receptor
CCR8
therapy resistance
temozolomide
RNAi screening
glycans
Online Access:http://dx.doi.org/10.1080/20013078.2018.1446660

Internet

http://dx.doi.org/10.1080/20013078.2018.1446660

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