Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrogenase (SDH) drives the ROS production that underli...

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Bibliographic Details
Main Authors: Timothy E. Beach, Hiran A. Prag, Laura Pala, Angela Logan, Margaret M. Huang, Anja V. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, Mazin O. Hamed, Sarah A. Hosgood, Michael L. Nicholson, Andrew M. James, Richard C. Hartley, Michael P. Murphy, Kourosh Saeb-Parsy
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Ischemia reperfusion injury
Malonate
Succinate
Mitochondria
Kidney
Succinate dehydrogenase
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308454

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http://www.sciencedirect.com/science/article/pii/S2213231720308454

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