Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism

Our genome is constantly exposed to endogenous and exogenous sources of DNA damage resulting in various alterations of the genetic code. DNA double-strand breaks (DSBs) are considered one of the most cytotoxic lesions. Several types of repair pathways act to repair DNA damage and maintain genome sta...

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Bibliographic Details
Main Authors: Kaspar Burger, Ruth F. Ketley, Monika Gullerova
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA damage response
RNA metabolism
phosphorylation
RNA polymerase II
dicer
kinase
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00061/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00061/full

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