Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. Whil...
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doaj-03e7c0169b1c4e198268c6691330f82e2020-11-25T00:46:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2018-08-01510.3389/fcvm.2018.00114381452Supplemental Oxygen Protects Heart Against Acute Myocardial InfarctionAnjali M. Prabhat0M. Lakshmi Kuppusamy1M. Lakshmi Kuppusamy2Shan K. Naidu3Sarath Meduru4Praneeth T. Reddy5Abishai Dominic6Mahmood Khan7Mahmood Khan8Brian K. Rivera9Periannan Kuppusamy10Periannan Kuppusamy11Departments of Radiology and Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, United StatesDepartments of Radiology and Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDepartment of Emergency Medicine, Ohio State University Wexner Medical Center, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesDepartments of Radiology and Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, United StatesDorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United StatesMyocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO2), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO2 under normobaric conditions was found to be effective for cardioprotection.https://www.frontiersin.org/article/10.3389/fcvm.2018.00114/fullsupplemental oxygenoxygen cyclingmyocardial infarctionischemia-reperfusion injuryoximetry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anjali M. Prabhat M. Lakshmi Kuppusamy M. Lakshmi Kuppusamy Shan K. Naidu Sarath Meduru Praneeth T. Reddy Abishai Dominic Mahmood Khan Mahmood Khan Brian K. Rivera Periannan Kuppusamy Periannan Kuppusamy |
spellingShingle |
Anjali M. Prabhat M. Lakshmi Kuppusamy M. Lakshmi Kuppusamy Shan K. Naidu Sarath Meduru Praneeth T. Reddy Abishai Dominic Mahmood Khan Mahmood Khan Brian K. Rivera Periannan Kuppusamy Periannan Kuppusamy Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction Frontiers in Cardiovascular Medicine supplemental oxygen oxygen cycling myocardial infarction ischemia-reperfusion injury oximetry |
author_facet |
Anjali M. Prabhat M. Lakshmi Kuppusamy M. Lakshmi Kuppusamy Shan K. Naidu Sarath Meduru Praneeth T. Reddy Abishai Dominic Mahmood Khan Mahmood Khan Brian K. Rivera Periannan Kuppusamy Periannan Kuppusamy |
author_sort |
Anjali M. Prabhat |
title |
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction |
title_short |
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction |
title_full |
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction |
title_fullStr |
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction |
title_full_unstemmed |
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction |
title_sort |
supplemental oxygen protects heart against acute myocardial infarction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2018-08-01 |
description |
Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO2), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO2 under normobaric conditions was found to be effective for cardioprotection. |
topic |
supplemental oxygen oxygen cycling myocardial infarction ischemia-reperfusion injury oximetry |
url |
https://www.frontiersin.org/article/10.3389/fcvm.2018.00114/full |
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