Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature

Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature

Valproic acid (VPA) is one of the most frequently used antiepileptic drugs for the treatment of focal and generalized epilepsies, absence seizures, and Lennox-Gastaut syndrome (LGS). VPA has been demonstrated to have a negative effect on both the intrinsic and extrinsic coagulation systems and contr...

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Main Authors: Francesco Inzirillo, Casimiro Giorgetta, Eugenio Ravalli, Claudio Della Pona
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Lung India
Subjects:
Alveolar hemorrhage
coagulation disorders
valproic acid
Online Access:http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=2;spage=175;epage=177;aulast=Inzirillo
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spelling doaj-03edeff9e1b84b738cd8b49b248678442020-11-24T22:51:14ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2015-01-0132217517710.4103/0970-2113.152646Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literatureFrancesco InzirilloCasimiro GiorgettaEugenio RavalliClaudio Della PonaValproic acid (VPA) is one of the most frequently used antiepileptic drugs for the treatment of focal and generalized epilepsies, absence seizures, and Lennox-Gastaut syndrome (LGS). VPA has been demonstrated to have a negative effect on both the intrinsic and extrinsic coagulation systems and controversy exists about the clinical relevance of such hematological abnormalities. We describe a case of reversible lung hemorrage due to VPA. In English-language literature only two other similar cases (one of which fatal) have been described so far.http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=2;spage=175;epage=177;aulast=InzirilloAlveolar hemorrhagecoagulation disordersvalproic acid
collection DOAJ
language English
format Article
sources DOAJ
author Francesco Inzirillo
Casimiro Giorgetta
Eugenio Ravalli
Claudio Della Pona
spellingShingle Francesco Inzirillo
Casimiro Giorgetta
Eugenio Ravalli
Claudio Della Pona
Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
Lung India
Alveolar hemorrhage
coagulation disorders
valproic acid
author_facet Francesco Inzirillo
Casimiro Giorgetta
Eugenio Ravalli
Claudio Della Pona
author_sort Francesco Inzirillo
title Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
title_short Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
title_full Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
title_fullStr Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
title_full_unstemmed Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature
title_sort diffuse alveolar hemorrhage due to valproic acid: case report and review of the literature
publisher Wolters Kluwer Medknow Publications
series Lung India
issn 0970-2113
0974-598X
publishDate 2015-01-01
description Valproic acid (VPA) is one of the most frequently used antiepileptic drugs for the treatment of focal and generalized epilepsies, absence seizures, and Lennox-Gastaut syndrome (LGS). VPA has been demonstrated to have a negative effect on both the intrinsic and extrinsic coagulation systems and controversy exists about the clinical relevance of such hematological abnormalities. We describe a case of reversible lung hemorrage due to VPA. In English-language literature only two other similar cases (one of which fatal) have been described so far.
topic Alveolar hemorrhage
coagulation disorders
valproic acid
url http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=2;spage=175;epage=177;aulast=Inzirillo
work_keys_str_mv AT francescoinzirillo diffusealveolarhemorrhageduetovalproicacidcasereportandreviewoftheliterature
AT casimirogiorgetta diffusealveolarhemorrhageduetovalproicacidcasereportandreviewoftheliterature
AT eugenioravalli diffusealveolarhemorrhageduetovalproicacidcasereportandreviewoftheliterature
AT claudiodellapona diffusealveolarhemorrhageduetovalproicacidcasereportandreviewoftheliterature
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