Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2

Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2

Randomized trials in acute promyelocytic leukemia patients have shown that treatment with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) is superior in efficacy to monotherapy, with significantly decreased mortality. So far, there are little data available to explain the...

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Bibliographic Details
Main Authors: Károly Jambrovics, Iván P. Uray, Jeffrey W. Keillor, László Fésüs, Zoltán Balajthy
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
acute promyelocytic leukemia
all-trans retinoic acid (atra)
arsenic trioxide (ato)
atra and ato combination treatment
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Online Access:https://www.mdpi.com/2072-6694/12/3/648

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https://www.mdpi.com/2072-6694/12/3/648

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