Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells

Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells

Dendritic cells (DCs) play a major role in innate and adaptive immunity and self-immune tolerance. Immunogenic versus tolerogenic DC functions are dictated by their levels of costimulatory molecules and their cytokine expression profile. The transcription factor C/EBPβ regulates the express...

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Bibliographic Details
Main Authors: Chantal Guindi, Alexandre Cloutier, Simon Gaudreau, Echarki Zerif, Patrick P. McDonald, Olga Tatsiy, Claude Asselin, Gilles Dupuis, Denis Gris, Abdelaziz Amrani
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cells
Subjects:
tolerogenic bone marrow-derived dendritic cells (BMDCs)
CCAAT/enhancer-binding protein beta (C/EBPβ)
Interleukins 10 and 12 (IL-10
IL-12)
Online Access:https://www.mdpi.com/2073-4409/7/12/256

Internet

https://www.mdpi.com/2073-4409/7/12/256

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