Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models

Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models

The pathological association of alpha-synuclein (SYN) and Tubulin Polymerization Promoting Protein (TPPP/p25) is a key factor in the etiology of synucleinopathies. In normal brains, the intrinsically disordered SYN and TPPP/p25 are not found together but exist separately in neurons and oligodendrocy...

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Bibliographic Details
Main Authors: Attila Lehotzky, Judit Oláh, János Tibor Fekete, Tibor Szénási, Edit Szabó, Balázs Győrffy, György Várady, Judit Ovádi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
parkinsonism
alpha-synuclein
TPPP/p25
autophagy inhibition
drug target
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.666026/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.666026/full

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