Lipossomas: a bala mágica acertou? Liposomes: has the magic bullet hit the target?

<abstract language="eng">Efficient drug delivery systems are as important as drug themselves. A powerful drug unable to reach the target cell is useless in practice. Ehrlich's Magic Bullet was the first carrier system to be proposed. The evolution in this domain has been quite s...

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Bibliographic Details
Main Authors: Nuno C. Santos, Miguel A. R. B. Castanho
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2002-12-01
Series:Química Nova
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700019
Description
Summary:<abstract language="eng">Efficient drug delivery systems are as important as drug themselves. A powerful drug unable to reach the target cell is useless in practice. Ehrlich's Magic Bullet was the first carrier system to be proposed. The evolution in this domain has been quite slow as the natural mechanisms of mammals against foreign products are hard to overcome. However, lipid-based systems (liposomes and related vesicles) have attained reasonable success. The basic preparations and structural features of liposomes and related vesicles as well as their applications are addressed from the chemist's and biochemist's point of view.
ISSN:0100-4042
1678-7064