Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction

Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction

How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two aspects of nuclear function.

Bibliographic Details
Main Authors: Stefano Gnan, Ilya M. Flyamer, Kyle N. Klein, Eleonora Castelli, Alexander Rapp, Andreas Maiser, Naiming Chen, Patrick Weber, Elin Enervald, M. Cristina Cardoso, Wendy A. Bickmore, David M. Gilbert, Sara C. B. Buonomo
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22899-2
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spelling doaj-051ec9ea54774968bffcfc289db433ad2021-05-23T11:13:07ZengNature Publishing GroupNature Communications2041-17232021-05-0112111010.1038/s41467-021-22899-2Nuclear organisation and replication timing are coupled through RIF1–PP1 interactionStefano Gnan0Ilya M. Flyamer1Kyle N. Klein2Eleonora Castelli3Alexander Rapp4Andreas Maiser5Naiming Chen6Patrick Weber7Elin Enervald8M. Cristina Cardoso9Wendy A. Bickmore10David M. Gilbert11Sara C. B. Buonomo12Epigenetics & Neurobiology Unit, European Molecular Biology Laboratory (EMBL Rome)MRC Human Genetics Unit, Institute of Genetics and Cancer, University of EdinburghDepartment of Biological Science, Florida State UniversityInstitute of Cell Biology, School of Biological Sciences University of EdinburghCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtDepartment of Biology II, LMU MunichInstitute of Cell Biology, School of Biological Sciences University of EdinburghCell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtEpigenetics & Neurobiology Unit, European Molecular Biology Laboratory (EMBL Rome)Cell Biology and Epigenetics, Department of Biology, Technical University of DarmstadtMRC Human Genetics Unit, Institute of Genetics and Cancer, University of EdinburghDepartment of Biological Science, Florida State UniversityEpigenetics & Neurobiology Unit, European Molecular Biology Laboratory (EMBL Rome)How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two aspects of nuclear function.https://doi.org/10.1038/s41467-021-22899-2
collection DOAJ
language English
format Article
sources DOAJ
author Stefano Gnan
Ilya M. Flyamer
Kyle N. Klein
Eleonora Castelli
Alexander Rapp
Andreas Maiser
Naiming Chen
Patrick Weber
Elin Enervald
M. Cristina Cardoso
Wendy A. Bickmore
David M. Gilbert
Sara C. B. Buonomo
spellingShingle Stefano Gnan
Ilya M. Flyamer
Kyle N. Klein
Eleonora Castelli
Alexander Rapp
Andreas Maiser
Naiming Chen
Patrick Weber
Elin Enervald
M. Cristina Cardoso
Wendy A. Bickmore
David M. Gilbert
Sara C. B. Buonomo
Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
Nature Communications
author_facet Stefano Gnan
Ilya M. Flyamer
Kyle N. Klein
Eleonora Castelli
Alexander Rapp
Andreas Maiser
Naiming Chen
Patrick Weber
Elin Enervald
M. Cristina Cardoso
Wendy A. Bickmore
David M. Gilbert
Sara C. B. Buonomo
author_sort Stefano Gnan
title Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
title_short Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
title_full Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
title_fullStr Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
title_full_unstemmed Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
title_sort nuclear organisation and replication timing are coupled through rif1–pp1 interaction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two aspects of nuclear function.
url https://doi.org/10.1038/s41467-021-22899-2
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