Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment

Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment

Background: The aim of this study was to explore the effects of endoplasmic reticulum (ER) stress on hepatitis B virus (HBV) replication and the antiviral effect of entecavir (ETV).Methods: Thapsigargin (TG) and stearic acid (SA) were used to induce ER stress in HepG2.2.15 cells and HepAD38 cells th...

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Bibliographic Details
Main Authors: Huan Chen, Maoyuan Mu, Qichuan Liu, Han Hu, Caiyun Tian, Guoyuan Zhang, Ying Li, Fangwan Yang, Shide Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
endoplasmic reticulum stress
HepG2215
thapsigargin
stearic acid
HBsAg
HBV DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2020.589040/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2020.589040/full

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