Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization
Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in musculoskeletal systems remains a challenge for researchers and surgeons, requiring the application of tissue engineering biomaterials. Successful application depends on the response of the host tissue to...
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Format: | Article |
Language: | English |
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KeAi Communications Co., Ltd.
2021-11-01
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Series: | Bioactive Materials |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21001869 |
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doaj-058087c75390467d90e028b70df45ce6 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinchun Ye Chang Xie Canlong Wang Jiayun Huang Zi Yin Boon Chin Heng Xiao Chen Weiliang Shen |
spellingShingle |
Jinchun Ye Chang Xie Canlong Wang Jiayun Huang Zi Yin Boon Chin Heng Xiao Chen Weiliang Shen Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization Bioactive Materials Biomaterials Drug delivery systems Macrophage polarization Musculoskeletal system soft tissue Regenerative medicine |
author_facet |
Jinchun Ye Chang Xie Canlong Wang Jiayun Huang Zi Yin Boon Chin Heng Xiao Chen Weiliang Shen |
author_sort |
Jinchun Ye |
title |
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
title_short |
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
title_full |
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
title_fullStr |
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
title_full_unstemmed |
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
title_sort |
promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-11-01 |
description |
Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in musculoskeletal systems remains a challenge for researchers and surgeons, requiring the application of tissue engineering biomaterials. Successful application depends on the response of the host tissue to the biomaterial and specific healing process of each anatomical structure. The commonly-held view is that biomaterials should be biocompatible to minimize local host immune response. However, a growing number of studies have shown that active modulation of the immune cells, particularly macrophages, via biomaterials is an effective way to control immune response and promote tissue regeneration as well as biomaterial integration. Therefore, we critically review the role of macrophages in the repair of injured musculoskeletal system soft tissues, which have relatively poor regenerative capacities, as well as discuss further enhancement of target tissue regeneration via modulation of macrophage polarization by biomaterial-mediated immunomodulation (biomaterial properties and delivery systems). This active regulation approach rather than passive-evade strategy maximizes the potential of biomaterials to promote musculoskeletal system soft tissue regeneration and provides alternative therapeutic options for repairing critical-sized defects. |
topic |
Biomaterials Drug delivery systems Macrophage polarization Musculoskeletal system soft tissue Regenerative medicine |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X21001869 |
work_keys_str_mv |
AT jinchunye promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT changxie promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT canlongwang promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT jiayunhuang promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT ziyin promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT boonchinheng promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT xiaochen promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization AT weiliangshen promotingmusculoskeletalsystemsofttissueregenerationbybiomaterialmediatedmodulationofmacrophagepolarization |
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1721209833109061632 |
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doaj-058087c75390467d90e028b70df45ce62021-08-12T04:35:13ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-11-0161140964109Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarizationJinchun Ye0Chang Xie1Canlong Wang2Jiayun Huang3Zi Yin4Boon Chin Heng5Xiao Chen6Weiliang Shen7Department of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, ChinaCentral Laboratories, Peking University School of Stomatology, Beijing, ChinaDepartment of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China; Corresponding author. Department of Orthopedic Surgery of The Second Affiliated Hospital and Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, 866 Yu Hang Tang Road, Hangzhou, Zhejiang, 310058, China.Department of Orthopedic Surgery (Sports Medicine) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China; Institute of Sports Medicine, Zhejiang University, Hangzhou, China; China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China; Corresponding author. Department of Orthopedic Surgery of The Second Affiliated Hospital and Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, 88 Jie Fang Road, Hangzhou, Zhejiang, 310009, China.Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in musculoskeletal systems remains a challenge for researchers and surgeons, requiring the application of tissue engineering biomaterials. Successful application depends on the response of the host tissue to the biomaterial and specific healing process of each anatomical structure. The commonly-held view is that biomaterials should be biocompatible to minimize local host immune response. However, a growing number of studies have shown that active modulation of the immune cells, particularly macrophages, via biomaterials is an effective way to control immune response and promote tissue regeneration as well as biomaterial integration. Therefore, we critically review the role of macrophages in the repair of injured musculoskeletal system soft tissues, which have relatively poor regenerative capacities, as well as discuss further enhancement of target tissue regeneration via modulation of macrophage polarization by biomaterial-mediated immunomodulation (biomaterial properties and delivery systems). This active regulation approach rather than passive-evade strategy maximizes the potential of biomaterials to promote musculoskeletal system soft tissue regeneration and provides alternative therapeutic options for repairing critical-sized defects.http://www.sciencedirect.com/science/article/pii/S2452199X21001869BiomaterialsDrug delivery systemsMacrophage polarizationMusculoskeletal system soft tissueRegenerative medicine |