Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site
BACKGROUND: An epidemic of asbestos-related disease is ongoing in most industrialized countries, mainly attributable to past occupational exposure but partly due to environmental exposure. In this perspective, the incidence of pleural mesothelioma close to a former asbestos-cement plant in a nationa...
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Istituto Superiore di Sanità
2014-12-01
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doaj-05d89b44a831460dad6cd66664d683972020-11-25T02:38:49ZengIstituto Superiore di SanitàAnnali dell'Istituto Superiore di Sanità0021-25712014-12-0150432232710.4415/ANN_14_04_05S0021-25712014000400005Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated siteLucia Fazzo0Simona Menegozzo1Maria Eleonora Soggiu2Marco De Santis3Michele Santoro4Valentina Cozza5Amelia Brangi6Massimo Menegozzo7Pietro Comba8Istituto Superiore di SanitàSeconda Università di NapoliIstituto Superiore di SanitàIstituto Superiore di SanitàConsiglio Nazionale delle RicercheSeconda Università di NapoliSeconda Università di NapoliSeconda Università di NapoliIstituto Superiore di SanitàBACKGROUND: An epidemic of asbestos-related disease is ongoing in most industrialized countries, mainly attributable to past occupational exposure but partly due to environmental exposure. In this perspective, the incidence of pleural mesothelioma close to a former asbestos-cement plant in a national contaminated site was estimated. METHODS: The census-tracts interested by atmospheric dispersion of facilities in the contaminated site were identified. Two subareas with different estimated environmental asbestos impact were distinguished. An ecological study at micro-geographic level was performed. The standardized incidence ratios (SIR) for study area and the two subareas, in comparison with region and municipality were computed. The standardized incidence rate ratio (IRR) between the two subareas was computed. RESULTS: Mesothelioma incidence in the study area was increased: 46 cases were observed with respect to 22.23 expected (SIR: 2.02). The increase was confirmed in analysis considering only the subjects without an occupationally exposure to asbestos: 19 cases among men (SIR = 2.48; 95% CI: 1.49-3.88); 11 case among women (SIR = 1.34; 95% CI: 0.67-2.40). The IRR between the two subareas is less than one in overall population considering all age-classes and of 3 fold (IRR = 3.14, 95% CI: 0.65-9.17) in the age-classes below 55 years. CONCLUSIONS: The findings indicate an increased incidence of pleural mesothelioma in the neighbourhood of asbestos-cement plant, and a possible etiological contribution of asbestos environmental exposure in detected risks.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712014000400005&lng=en&tlng=enmesotheliomaincidenceasbestoscontaminated siteenvironmental exposure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucia Fazzo Simona Menegozzo Maria Eleonora Soggiu Marco De Santis Michele Santoro Valentina Cozza Amelia Brangi Massimo Menegozzo Pietro Comba |
spellingShingle |
Lucia Fazzo Simona Menegozzo Maria Eleonora Soggiu Marco De Santis Michele Santoro Valentina Cozza Amelia Brangi Massimo Menegozzo Pietro Comba Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site Annali dell'Istituto Superiore di Sanità mesothelioma incidence asbestos contaminated site environmental exposure |
author_facet |
Lucia Fazzo Simona Menegozzo Maria Eleonora Soggiu Marco De Santis Michele Santoro Valentina Cozza Amelia Brangi Massimo Menegozzo Pietro Comba |
author_sort |
Lucia Fazzo |
title |
Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
title_short |
Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
title_full |
Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
title_fullStr |
Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
title_full_unstemmed |
Mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
title_sort |
mesothelioma incidence in the neighbourhood of an asbestos-cement plant located in a national priority contaminated site |
publisher |
Istituto Superiore di Sanità |
series |
Annali dell'Istituto Superiore di Sanità |
issn |
0021-2571 |
publishDate |
2014-12-01 |
description |
BACKGROUND: An epidemic of asbestos-related disease is ongoing in most industrialized countries, mainly attributable to past occupational exposure but partly due to environmental exposure. In this perspective, the incidence of pleural mesothelioma close to a former asbestos-cement plant in a national contaminated site was estimated. METHODS: The census-tracts interested by atmospheric dispersion of facilities in the contaminated site were identified. Two subareas with different estimated environmental asbestos impact were distinguished. An ecological study at micro-geographic level was performed. The standardized incidence ratios (SIR) for study area and the two subareas, in comparison with region and municipality were computed. The standardized incidence rate ratio (IRR) between the two subareas was computed. RESULTS: Mesothelioma incidence in the study area was increased: 46 cases were observed with respect to 22.23 expected (SIR: 2.02). The increase was confirmed in analysis considering only the subjects without an occupationally exposure to asbestos: 19 cases among men (SIR = 2.48; 95% CI: 1.49-3.88); 11 case among women (SIR = 1.34; 95% CI: 0.67-2.40). The IRR between the two subareas is less than one in overall population considering all age-classes and of 3 fold (IRR = 3.14, 95% CI: 0.65-9.17) in the age-classes below 55 years. CONCLUSIONS: The findings indicate an increased incidence of pleural mesothelioma in the neighbourhood of asbestos-cement plant, and a possible etiological contribution of asbestos environmental exposure in detected risks. |
topic |
mesothelioma incidence asbestos contaminated site environmental exposure |
url |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712014000400005&lng=en&tlng=en |
work_keys_str_mv |
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