In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis

In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis

The emergence and continued spread of SARS-CoV-2 have resulted in a public health emergency across the globe. The lack of knowledge on the precise mechanism of viral pathogenesis is impeding medical intervention. In this study, we have taken both in silico and in vitro experimental approaches to unr...

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Bibliographic Details
Main Authors: Ritudhwaj Tiwari, Anurag R. Mishra, Flora Mikaeloff, Soham Gupta, Ali Mirazimi, Siddappa N. Byrareddy, Ujjwal Neogi, Debasis Nayak
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
Thrombosis
MAPK1/MAPK3
ARDS
Cytokines storm
Neutrophil degranulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304724

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http://www.sciencedirect.com/science/article/pii/S2001037020304724

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