AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

Abstract Introduction The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke. Methods Lung tissue, bronchoscopy-derived alveolar macrophages an...

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Bibliographic Details
Main Authors: Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant, Sandra J. Hodge
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Inflammation
Subjects:
AIM2 inflammasome
AIM2 protein nuclear localization
COPD
Cigarette smoke
Online Access:https://doi.org/10.1186/s12950-021-00286-4

Internet

https://doi.org/10.1186/s12950-021-00286-4

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