Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to associate with silent genes. Here, we use a cell model of neural differentiation, which upon PRMT6 knockout exhibits proliferation and diffe...

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Bibliographic Details
Main Authors: Caroline Bouchard, Peeyush Sahu, Marion Meixner, René Reiner Nötzold, Marco B. Rust, Elisabeth Kremmer, Regina Feederle, Gene Hart-Smith, Florian Finkernagel, Marek Bartkuhn, Soni Savai Pullamsetti, Andrea Nist, Thorsten Stiewe, Sjaak Philipsen, Uta-Maria Bauer
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831338X

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http://www.sciencedirect.com/science/article/pii/S221112471831338X

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