Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2

The present article describes clinical signs of meningococcal disease. It justifies the necessity of its vaccine prevention. The article provides with the historical data on the evolution of inoculants from corpuscular inactivated vaccines to modern chemical polyvalent vaccines. It provides a glimps...

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Main Authors: M. V. Abramtseva, A. P. Tarasov, T. I. Nemirovskaya
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
Online Access:https://www.biopreparations.ru/jour/article/view/19
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spelling doaj-065b8ec276cc4ba8a9ebe5f5dbd2ea232021-07-28T14:03:33ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0103253319Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2M. V. Abramtseva0A. P. Tarasov1T. I. Nemirovskaya2Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФедеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФедеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииThe present article describes clinical signs of meningococcal disease. It justifies the necessity of its vaccine prevention. The article provides with the historical data on the evolution of inoculants from corpuscular inactivated vaccines to modern chemical polyvalent vaccines. It provides a glimpse of the efficacy of the use of corpuscular vaccines and considers the corresponding implications. The historical overview includes the use of mono-, di-, tetravalent polysaccharide vaccines, and the discussion on the role of bactericidal antibodies in the formation of immunity against meningococcal disease. The article also describes the experience of using polysaccharide vaccines in various countries and in different age groups in randomized clinical trials. It provides with the data analysis about the effect of vaccination on the level of meningococcal carriage and the incidence of meningococcal disease. The WHO’s position on the use of polysaccharide meningococcal vaccines in routine practice are also provided. In the conclusion the article presents the prospects for further use of polysaccharide vaccines to control the spread of meningococcal disease.https://www.biopreparations.ru/jour/article/view/19менингококковая инфекциягенерализированные формы менингококковой инфекциименингококковый менингиткапсульные полисахаридыменингококковые вакциныреактогенностьиммуногенностьпротективный иммунитетполисахаридные вакциныmeningococcal diseasegeneralized forms of meningococcal diseasemeningococcal meningitiscapsular polysaccharidesmeningococcal vaccinesreactivityimmunogenicityprotective immunitypolysaccharide vaccines
collection DOAJ
language Russian
format Article
sources DOAJ
author M. V. Abramtseva
A. P. Tarasov
T. I. Nemirovskaya
spellingShingle M. V. Abramtseva
A. P. Tarasov
T. I. Nemirovskaya
Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
Биопрепараты: Профилактика, диагностика, лечение
менингококковая инфекция
генерализированные формы менингококковой инфекции
менингококковый менингит
капсульные полисахариды
менингококковые вакцины
реактогенность
иммуногенность
протективный иммунитет
полисахаридные вакцины
meningococcal disease
generalized forms of meningococcal disease
meningococcal meningitis
capsular polysaccharides
meningococcal vaccines
reactivity
immunogenicity
protective immunity
polysaccharide vaccines
author_facet M. V. Abramtseva
A. P. Tarasov
T. I. Nemirovskaya
author_sort M. V. Abramtseva
title Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
title_short Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
title_full Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
title_fullStr Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
title_full_unstemmed Meningococcal disease. Polysaccharide meningococcal vaccines. The historical aspects and the current state of vaccine development. Report 2
title_sort meningococcal disease. polysaccharide meningococcal vaccines. the historical aspects and the current state of vaccine development. report 2
publisher Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
series Биопрепараты: Профилактика, диагностика, лечение
issn 2221-996X
2619-1156
publishDate 2018-02-01
description The present article describes clinical signs of meningococcal disease. It justifies the necessity of its vaccine prevention. The article provides with the historical data on the evolution of inoculants from corpuscular inactivated vaccines to modern chemical polyvalent vaccines. It provides a glimpse of the efficacy of the use of corpuscular vaccines and considers the corresponding implications. The historical overview includes the use of mono-, di-, tetravalent polysaccharide vaccines, and the discussion on the role of bactericidal antibodies in the formation of immunity against meningococcal disease. The article also describes the experience of using polysaccharide vaccines in various countries and in different age groups in randomized clinical trials. It provides with the data analysis about the effect of vaccination on the level of meningococcal carriage and the incidence of meningococcal disease. The WHO’s position on the use of polysaccharide meningococcal vaccines in routine practice are also provided. In the conclusion the article presents the prospects for further use of polysaccharide vaccines to control the spread of meningococcal disease.
topic менингококковая инфекция
генерализированные формы менингококковой инфекции
менингококковый менингит
капсульные полисахариды
менингококковые вакцины
реактогенность
иммуногенность
протективный иммунитет
полисахаридные вакцины
meningococcal disease
generalized forms of meningococcal disease
meningococcal meningitis
capsular polysaccharides
meningococcal vaccines
reactivity
immunogenicity
protective immunity
polysaccharide vaccines
url https://www.biopreparations.ru/jour/article/view/19
work_keys_str_mv AT mvabramtseva meningococcaldiseasepolysaccharidemeningococcalvaccinesthehistoricalaspectsandthecurrentstateofvaccinedevelopmentreport2
AT aptarasov meningococcaldiseasepolysaccharidemeningococcalvaccinesthehistoricalaspectsandthecurrentstateofvaccinedevelopmentreport2
AT tinemirovskaya meningococcaldiseasepolysaccharidemeningococcalvaccinesthehistoricalaspectsandthecurrentstateofvaccinedevelopmentreport2
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