Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting. We have identified a genetically and functionally distinct subset of dynamic bone marrow myeloid cells...

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Bibliographic Details
Main Authors: Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A. Friedman, Timothy H. Chu, Michael J. Churchill, Yan Ma, Karan K. Nagar, Yagnesh H. Tailor, Siddhartha Mukherjee, Timothy C. Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:OncoImmunology
Subjects:
colitis-associated colorectal cancer
cxcl13/cxcr5 axis
hdc+ myeloid cells
immunosuppression
regulatory t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1290034

Internet

http://dx.doi.org/10.1080/2162402X.2017.1290034

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