2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression

2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression

Magnolia officinalis is widely used in Southeast Asian countries for the treatment of fever, headache, diarrhea, and stroke. Magnolol is a phenolic compound extracted from M. officinalis, with proven antibacterial, antioxidant, anti-inflammatory, and anticancer activities. In this study, we modified...

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Bibliographic Details
Main Authors: Chi-Yuan Chen, Jia-You Fang, Chin-Chuan Chen, Wen-Yu Chuang, Yann-Lii Leu, Shir-Hwa Ueng, Li-Shan Wei, Shu-Fang Cheng, Chuen Hsueh, Tong-Hong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
magnolol
2-O-methylmagnolol (MM1)
histone deacetylase (HDAC)
hepatocellular carcinoma (HCC)
p21
p53
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01319/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01319/full

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