Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment
The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria. It is mediated by the alarmone (p)ppGpp and the regulatory molecule inorganic polyphosphate in respon...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.744167/full |
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doaj-070941fdc4ce4b3eb46f8d6289cdd7362021-10-07T08:05:20ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-10-011210.3389/fmicb.2021.744167744167Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis TreatmentCarina DanchikSiqing WangPetros C. KarakousisThe stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria. It is mediated by the alarmone (p)ppGpp and the regulatory molecule inorganic polyphosphate in response to stress conditions such as nutrient starvation. Efforts to pharmacologically target various components of the stringent response have shown promise in modulating mycobacterial virulence and antibiotic tolerance. In this review, we summarize the current understanding of the stringent response and its role in virulence and tolerance in Mycobacteria, including evidence that targeting this pathway could have therapeutic benefit.https://www.frontiersin.org/articles/10.3389/fmicb.2021.744167/fullMycobacterium tuberculosisstringent responseantibiotic tolerance(p)ppGpphyperphosphorylated guanosineinorganic polyphosphate |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carina Danchik Siqing Wang Petros C. Karakousis |
| spellingShingle |
Carina Danchik Siqing Wang Petros C. Karakousis Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment Frontiers in Microbiology Mycobacterium tuberculosis stringent response antibiotic tolerance (p)ppGpp hyperphosphorylated guanosine inorganic polyphosphate |
| author_facet |
Carina Danchik Siqing Wang Petros C. Karakousis |
| author_sort |
Carina Danchik |
| title |
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment |
| title_short |
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment |
| title_full |
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment |
| title_fullStr |
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment |
| title_full_unstemmed |
Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment |
| title_sort |
targeting the mycobacterium tuberculosis stringent response as a strategy for shortening tuberculosis treatment |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Microbiology |
| issn |
1664-302X |
| publishDate |
2021-10-01 |
| description |
The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria. It is mediated by the alarmone (p)ppGpp and the regulatory molecule inorganic polyphosphate in response to stress conditions such as nutrient starvation. Efforts to pharmacologically target various components of the stringent response have shown promise in modulating mycobacterial virulence and antibiotic tolerance. In this review, we summarize the current understanding of the stringent response and its role in virulence and tolerance in Mycobacteria, including evidence that targeting this pathway could have therapeutic benefit. |
| topic |
Mycobacterium tuberculosis stringent response antibiotic tolerance (p)ppGpp hyperphosphorylated guanosine inorganic polyphosphate |
| url |
https://www.frontiersin.org/articles/10.3389/fmicb.2021.744167/full |
| work_keys_str_mv |
AT carinadanchik targetingthemycobacteriumtuberculosisstringentresponseasastrategyforshorteningtuberculosistreatment AT siqingwang targetingthemycobacteriumtuberculosisstringentresponseasastrategyforshorteningtuberculosistreatment AT petrosckarakousis targetingthemycobacteriumtuberculosisstringentresponseasastrategyforshorteningtuberculosistreatment |
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