Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt".

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt".

Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endemic Burkitt Lymphoma (eBL), a pediatric cancer that...

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Bibliographic Details
Main Authors: Mateus H Gouveia, Andrew W Bergen, Victor Borda, Kelly Nunes, Thiago P Leal, Martin D Ogwang, Edward D Yeboah, James E Mensah, Tobias Kinyera, Isaac Otim, Hadijah Nabalende, Ismail D Legason, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Patrick Kerchan, Kishor Bhatia, Steven J Reynolds, Richard B Birtwum, Andrew A Adjei, Yao Tettey, Evelyn Tay, Robert Hoover, Ruth M Pfeiffer, Robert J Biggar, James J Goedert, Ludmila Prokunina-Olsson, Michael Dean, Meredith Yeager, M Fernanda Lima-Costa, Ann W Hsing, Sarah A Tishkoff, Stephen J Chanock, Eduardo Tarazona-Santos, Sam M Mbulaiteye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6426263?pdf=render

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http://europepmc.org/articles/PMC6426263?pdf=render

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