Polycystins and Mechanotransduction in Human Disease
Alterations in the process of mechanotransduction have been implicated in the pathogenesis of several diseases such as genetic diseases, osteoporosis, cardiovascular anomalies, and cancer. Several studies over the past twenty years have demonstrated that polycystins (polycystin-1, PC1; and polycysti...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/9/2182 |
id |
doaj-07253907f66846a2b52c835c451bd139 |
---|---|
record_format |
Article |
spelling |
doaj-07253907f66846a2b52c835c451bd1392020-11-25T02:18:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-01209218210.3390/ijms20092182ijms20092182Polycystins and Mechanotransduction in Human DiseaseAntonios N. Gargalionis0Efthimia K. Basdra1Athanasios G. Papavassiliou2Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceAlterations in the process of mechanotransduction have been implicated in the pathogenesis of several diseases such as genetic diseases, osteoporosis, cardiovascular anomalies, and cancer. Several studies over the past twenty years have demonstrated that polycystins (polycystin-1, PC1; and polycystin-2, PC2) respond to changes of extracellular mechanical cues, and mediate pathogenic mechanotransduction and cyst formation in kidney cells. However, recent reports reveal the emergence of polycystins as key proteins that facilitate the transduction of mechano-induced signals in various clinical entities besides polycystic kidney disease, such as cancer, cardiovascular defects, bone loss, and deformations, as well as inflammatory processes like psoriasis. Herewith, we discuss data from recent studies that establish this role with potential clinical utility.https://www.mdpi.com/1422-0067/20/9/2182mechanotransductionpolycystincancermetastasiscyst formationosteoblast differentiationpsoriasiscardiomyopathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonios N. Gargalionis Efthimia K. Basdra Athanasios G. Papavassiliou |
spellingShingle |
Antonios N. Gargalionis Efthimia K. Basdra Athanasios G. Papavassiliou Polycystins and Mechanotransduction in Human Disease International Journal of Molecular Sciences mechanotransduction polycystin cancer metastasis cyst formation osteoblast differentiation psoriasis cardiomyopathy |
author_facet |
Antonios N. Gargalionis Efthimia K. Basdra Athanasios G. Papavassiliou |
author_sort |
Antonios N. Gargalionis |
title |
Polycystins and Mechanotransduction in Human Disease |
title_short |
Polycystins and Mechanotransduction in Human Disease |
title_full |
Polycystins and Mechanotransduction in Human Disease |
title_fullStr |
Polycystins and Mechanotransduction in Human Disease |
title_full_unstemmed |
Polycystins and Mechanotransduction in Human Disease |
title_sort |
polycystins and mechanotransduction in human disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-05-01 |
description |
Alterations in the process of mechanotransduction have been implicated in the pathogenesis of several diseases such as genetic diseases, osteoporosis, cardiovascular anomalies, and cancer. Several studies over the past twenty years have demonstrated that polycystins (polycystin-1, PC1; and polycystin-2, PC2) respond to changes of extracellular mechanical cues, and mediate pathogenic mechanotransduction and cyst formation in kidney cells. However, recent reports reveal the emergence of polycystins as key proteins that facilitate the transduction of mechano-induced signals in various clinical entities besides polycystic kidney disease, such as cancer, cardiovascular defects, bone loss, and deformations, as well as inflammatory processes like psoriasis. Herewith, we discuss data from recent studies that establish this role with potential clinical utility. |
topic |
mechanotransduction polycystin cancer metastasis cyst formation osteoblast differentiation psoriasis cardiomyopathy |
url |
https://www.mdpi.com/1422-0067/20/9/2182 |
work_keys_str_mv |
AT antoniosngargalionis polycystinsandmechanotransductioninhumandisease AT efthimiakbasdra polycystinsandmechanotransductioninhumandisease AT athanasiosgpapavassiliou polycystinsandmechanotransductioninhumandisease |
_version_ |
1724883086780399616 |