Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes

Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes

Tumor associated macrophages are an essential part of the tumor microenvironment. Consequently, bone marrow-derived monocytes (BMDMs) are continuously recruited to tumors and are therefore seen as ideal delivery vehicles with tumor-targeting properties. By using immune cell depleting agents and macr...

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Bibliographic Details
Main Authors: Francis Combes, Alexandros Marios Sofias, Séan Mc Cafferty, Hanne Huysmans, Joyca De Temmerman, Sjoerd Hak, Evelyne Meyer, Niek N. Sanders
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
bmdm
depletion
phagocytes
competition
clodronate
intravital microscopy
fluorescence
Online Access:https://www.mdpi.com/2072-6694/11/11/1752

Internet

https://www.mdpi.com/2072-6694/11/11/1752

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