Estrogenic receptors a and p gene polymorphisms in postmenopausal osteoporosis

• Main Authors: K A Maslova, M Y Krylov, N V Toroptsova, O A Nikitinskaya, T A Korotkova, V A Myakotkin, L L Benevolenskaya
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2008-06-01
• Series: Научно-практическая ревматология
• Subjects: postmenopausal osteoporosis; estrogen receptor genes; risk and protection genotypes
• Online Access: https://rsp.mediar-press.net/rsp/article/view/791

Objective. To assess frequency distribution of estrogenic receptor (ER)a and ERfl gene polymorphisms and their influence on bone mineral density (BMD) in groups of postmenopausal women with and without osteoporosis (OP). Material and methods. 200 residents of Moscow and Moscow region were divided into two groups considering BMD values according to WHO criteria; OP group and healthy control group Results. Differences of genotype and their combinations frequency distribution between OP and control groups show presence OP risk and protector genotypes. ER gene important role in pathogenesis of postmenopausal osteoporosis and possibility to use these genetic markers for assessment of risk of OP development in Russian population was confirmed.