Inhibition of Geranylgeranyl Transferase-I Decreases Cell Viability of HTLV-1-Transformed Cells

Inhibition of Geranylgeranyl Transferase-I Decreases Cell Viability of HTLV-1-Transformed Cells

Human T-cell leukemia virus type-1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), an aggressive and highly chemoresistant malignancy. Rho family GTPases regulate multiple signaling pathways in tumorigenesis: cytoskeletal organization, transcription, cell cycle progression, and cel...

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Bibliographic Details
Main Authors: Cynthia A. Pise-Masison, Kyung-Jin Jung, John N. Brady, Claudio Fenizia, Katherine M. McKinnon, Dustin C. Edwards
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Viruses
Subjects:
human T-cell leukemia virus type-1
HTLV-1
Tax
long terminal repeat
LTR
geranylgeranyltransferase
GGTI-298
small GTPase
NF-κB
p53
cell cycle
Online Access:http://www.mdpi.com/1999-4915/3/10/1815/

Internet

http://www.mdpi.com/1999-4915/3/10/1815/

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