BNIP3 in Lung Cancer: To Kill or Rescue?
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy...
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doaj-07781204a01d4de5b2b4f930443012062020-11-25T04:03:49ZengMDPI AGCancers2072-66942020-11-01123390339010.3390/cancers12113390BNIP3 in Lung Cancer: To Kill or Rescue?Anna S. Gorbunova0Maria A. Yapryntseva1Tatiana V. Denisenko2Boris Zhivotovsky3Faculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, RussiaFaculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, RussiaFaculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, RussiaFaculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, RussiaBcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.https://www.mdpi.com/2072-6694/12/11/3390BNIP3lung cancerapoptosisautophagymetastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna S. Gorbunova Maria A. Yapryntseva Tatiana V. Denisenko Boris Zhivotovsky |
spellingShingle |
Anna S. Gorbunova Maria A. Yapryntseva Tatiana V. Denisenko Boris Zhivotovsky BNIP3 in Lung Cancer: To Kill or Rescue? Cancers BNIP3 lung cancer apoptosis autophagy metastasis |
author_facet |
Anna S. Gorbunova Maria A. Yapryntseva Tatiana V. Denisenko Boris Zhivotovsky |
author_sort |
Anna S. Gorbunova |
title |
BNIP3 in Lung Cancer: To Kill or Rescue? |
title_short |
BNIP3 in Lung Cancer: To Kill or Rescue? |
title_full |
BNIP3 in Lung Cancer: To Kill or Rescue? |
title_fullStr |
BNIP3 in Lung Cancer: To Kill or Rescue? |
title_full_unstemmed |
BNIP3 in Lung Cancer: To Kill or Rescue? |
title_sort |
bnip3 in lung cancer: to kill or rescue? |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-11-01 |
description |
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3. |
topic |
BNIP3 lung cancer apoptosis autophagy metastasis |
url |
https://www.mdpi.com/2072-6694/12/11/3390 |
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AT annasgorbunova bnip3inlungcancertokillorrescue AT mariaayapryntseva bnip3inlungcancertokillorrescue AT tatianavdenisenko bnip3inlungcancertokillorrescue AT boriszhivotovsky bnip3inlungcancertokillorrescue |
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