Systematic functional interrogation of human pseudogenes using CRISPRi

Systematic functional interrogation of human pseudogenes using CRISPRi

Abstract Background The human genome encodes over 14,000 pseudogenes that are evolutionary relics of protein-coding genes and commonly considered as nonfunctional. Emerging evidence suggests that some pseudogenes may exert important functions. However, to what extent human pseudogenes are functional...

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Bibliographic Details
Main Authors: Ming Sun, Yunfei Wang, Caishang Zheng, Yanjun Wei, Jiakai Hou, Peng Zhang, Wei He, Xiangdong Lv, Yao Ding, Han Liang, Chung-Chau Hon, Xi Chen, Han Xu, Yiwen Chen
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Biology
Subjects:
Pseudogene
Unitary pseudogene
CRISPR interference
Cancer
Luminal A breast cancer
Nucleus
Online Access:https://doi.org/10.1186/s13059-021-02464-2

Internet

https://doi.org/10.1186/s13059-021-02464-2

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