Trial Sequential Analysis in systematic reviews with meta-analysis

Abstract Background Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded as an interim analysis on its way towards a required information size....

Full description

Bibliographic Details
Main Authors: Jørn Wetterslev, Janus Christian Jakobsen, Christian Gluud
Format: Article
Published: BMC 2017-03-01
Series:BMC Medical Research Methodology
Online Access: