Trial Sequential Analysis in systematic reviews with meta-analysis

Trial Sequential Analysis in systematic reviews with meta-analysis

Abstract Background Most meta-analyses in systematic reviews, including Cochrane ones, do not have sufficient statistical power to detect or refute even large intervention effects. This is why a meta-analysis ought to be regarded as an interim analysis on its way towards a required information size....

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Bibliographic Details
Main Authors: Jørn Wetterslev, Janus Christian Jakobsen, Christian Gluud
Format: Article
Language:English
Published: BMC 2017-03-01
Series:BMC Medical Research Methodology
Subjects:
Meta-analysis
Random-effects model
Fixed-effect model
Interim analysis
Group sequential analysis
Trial sequential analysis
Online Access:http://link.springer.com/article/10.1186/s12874-017-0315-7

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http://link.springer.com/article/10.1186/s12874-017-0315-7

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