Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

Summary: Here, using single-cell RNA sequencing, we examine the stromal compartment in murine melanoma and draining lymph nodes (LNs) at points across tumor development, providing data at http://www.teichlab.org/data/. Naive lymphocytes from LNs undergo activation and clonal expansion within the tum...

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Bibliographic Details
Main Authors: Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A. Haniffa, Jacqueline D. Shields, Sarah A. Teichmann
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
melanoma
cancer-associated fibroblast
tumour microenvironment
single-cell sequencing
cell-cell communication
stroma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305817

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http://www.sciencedirect.com/science/article/pii/S2211124720305817

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