Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay
Bismuth oxide is one of the important transition metal oxides and it has been intensively studied due to their peculiar characteristics (semiconductor band gap, high refractive index, high dielectric permittivity, high oxygen conductivity, resistivity, photoconductivity and photoluminescence etc.)....
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doaj-0890291ff5f04a0ca040fd9e2aae7ede2020-11-24T22:00:50ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-06-01610.3389/conf.fgene.2015.01.00010151847Genotoxic effects of bismuth (III) oxide nanoparticles by comet assayReecep Liman0Muhsin Konuk1İbrahim Hakkı Ciğerci2Uşak UniversityÜsküdar UniversityAfyon Kocatepe UniversityBismuth oxide is one of the important transition metal oxides and it has been intensively studied due to their peculiar characteristics (semiconductor band gap, high refractive index, high dielectric permittivity, high oxygen conductivity, resistivity, photoconductivity and photoluminescence etc.). Therefore, it is used such as microelectronics, sensor technology, optical coatings, transparent ceramic glass manufacturing, nanoenergetic gas generator, biosensor for DNA hybridization, potential immobilizing platforms for glucose oxidase and polyphenol oxidase, fuel cells, a additive in paints, an astringent in a variety of medical creams and topical ointments, and for the determination of heavy metal ions in drinking water, mineral water and urine. In addition this, Bismuth (III) oxide nanoparticles (BONPs) are favorable for the biomolecules adsorption than regular sized particles because of their greater advantages and novel characteristics (much higher specific surface, greater surface free energy, and good electrochemical stability etc.). Genotoxic effects of BONPs were investigated on the root cells of Allium cepa by Comet assay. A. cepa roots were treated with the aqueous dispersions of BONPs at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. A significant increase in DNA damage was also observed at all concentrations of BONPs except 12.5 ppm by Comet assay. The results were also analyzed statistically by using SPSS for Windows; Duncan’s multiple range test was performed. These result indicate that BONPs exhibit genotoxic activity in A. cepa root meristematic cells.http://journal.frontiersin.org/Journal/10.3389/conf.fgene.2015.01.00010/fullAlliumDNA DamageNanoparticlesbismuth oxideComet |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Reecep Liman Muhsin Konuk İbrahim Hakkı Ciğerci |
spellingShingle |
Reecep Liman Muhsin Konuk İbrahim Hakkı Ciğerci Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay Frontiers in Genetics Allium DNA Damage Nanoparticles bismuth oxide Comet |
author_facet |
Reecep Liman Muhsin Konuk İbrahim Hakkı Ciğerci |
author_sort |
Reecep Liman |
title |
Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay |
title_short |
Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay |
title_full |
Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay |
title_fullStr |
Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay |
title_full_unstemmed |
Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay |
title_sort |
genotoxic effects of bismuth (iii) oxide nanoparticles by comet assay |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2015-06-01 |
description |
Bismuth oxide is one of the important transition metal oxides and it has been intensively studied due to their peculiar characteristics (semiconductor band gap, high refractive index, high dielectric permittivity, high oxygen conductivity, resistivity, photoconductivity and photoluminescence etc.). Therefore, it is used such as microelectronics, sensor technology, optical coatings, transparent ceramic glass manufacturing, nanoenergetic gas generator, biosensor for DNA hybridization, potential immobilizing platforms for glucose oxidase and polyphenol oxidase, fuel cells, a additive in paints, an astringent in a variety of medical creams and topical ointments, and for the determination of heavy metal ions in drinking water, mineral water and urine. In addition this, Bismuth (III) oxide nanoparticles (BONPs) are favorable for the biomolecules adsorption than regular sized particles because of their greater advantages and novel characteristics (much higher specific surface, greater surface free energy, and good electrochemical stability etc.).
Genotoxic effects of BONPs were investigated on the root cells of Allium cepa by Comet assay. A. cepa roots were treated with the aqueous dispersions of BONPs at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. A significant increase in DNA damage was also observed at all concentrations of BONPs except 12.5 ppm by Comet assay. The results were also analyzed statistically by using SPSS for Windows; Duncan’s multiple range test was performed. These result indicate that BONPs exhibit genotoxic activity in A. cepa root meristematic cells. |
topic |
Allium DNA Damage Nanoparticles bismuth oxide Comet |
url |
http://journal.frontiersin.org/Journal/10.3389/conf.fgene.2015.01.00010/full |
work_keys_str_mv |
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