A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death
nc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide...
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doaj-089d42cbfd874b7f8c64a7f8c09565dc2020-11-25T00:21:15ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-10-011310131341313910.3390/ijms131013134A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell DeathYong Sun LeeBetty H. JohnsonSung Ho Jeonnc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide range of cancer cells, the nc886-PKR relationship suggests a tumor surveillance model. When neoplastic cells develop and nc886 decreases therein, PKR is released from nc886 and becomes the active phosphorylated form, which initiates an apoptotic cascade to eliminate those cells. The nc886-PKR pathway is distinct from conventional mechanisms, such as the immune surveillance hypothesis or intrinsic mechanisms that check/proofread the genomic integrity, and thus represents a novel example of tumor surveillance.http://www.mdpi.com/1422-0067/13/10/13134nc886non-coding RNAPKR (Protein Kinase R)tumorsurveillance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Sun Lee Betty H. Johnson Sung Ho Jeon |
spellingShingle |
Yong Sun Lee Betty H. Johnson Sung Ho Jeon A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death International Journal of Molecular Sciences nc886 non-coding RNA PKR (Protein Kinase R) tumor surveillance |
author_facet |
Yong Sun Lee Betty H. Johnson Sung Ho Jeon |
author_sort |
Yong Sun Lee |
title |
A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death |
title_short |
A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death |
title_full |
A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death |
title_fullStr |
A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death |
title_full_unstemmed |
A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death |
title_sort |
tumor surveillance model: a non-coding rna senses neoplastic cells and its protein partner signals cell death |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2012-10-01 |
description |
nc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide range of cancer cells, the nc886-PKR relationship suggests a tumor surveillance model. When neoplastic cells develop and nc886 decreases therein, PKR is released from nc886 and becomes the active phosphorylated form, which initiates an apoptotic cascade to eliminate those cells. The nc886-PKR pathway is distinct from conventional mechanisms, such as the immune surveillance hypothesis or intrinsic mechanisms that check/proofread the genomic integrity, and thus represents a novel example of tumor surveillance. |
topic |
nc886 non-coding RNA PKR (Protein Kinase R) tumor surveillance |
url |
http://www.mdpi.com/1422-0067/13/10/13134 |
work_keys_str_mv |
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