A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of...

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Bibliographic Details
Main Authors: Martin A Bewley, Helen M Marriott, Calogero Tulone, Sheila E Francis, Timothy J Mitchell, Robert C Read, Benny Chain, Guido Kroemer, Moira K B Whyte, David H Dockrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21298030/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21298030/pdf/?tool=EBI

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