Effect of tolvaptan on renal handling of water and sodium, GFR and central hemodynamics in autosomal dominant polycystic kidney disease during inhibition of the nitric oxide system: a randomized, placebo-controlled, double blind, crossover study

Effect of tolvaptan on renal handling of water and sodium, GFR and central hemodynamics in autosomal dominant polycystic kidney disease during inhibition of the nitric oxide system: a randomized, placebo-controlled, double blind, crossover study

Abstract Background Tolvaptan slows progression of autosomal dominant polycystic kidney disease (ADPKD) by antagonizing the vasopressin-cAMP axis. Nitric oxide (NO) stimulates natriuresis and diuresis, but its role is unknown during tolvaptan treatment in ADPKD. Methods Eighteen patients with ADPKD...

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Bibliographic Details
Main Authors: Safa Al Therwani, My Emma Sofie Malmberg, Jeppe Bakkestroem Rosenbaek, Jesper Noergaard Bech, Erling Bjerregaard Pedersen
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Nephrology
Subjects:
Tolvaptan
ADPKD
Nitric oxide
ENaC
AQP2
Blood pressure
Online Access:http://link.springer.com/article/10.1186/s12882-017-0686-3

Internet

http://link.springer.com/article/10.1186/s12882-017-0686-3

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