Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient
Dysbiosis of the microbiome is a common finding in critically ill patients, who receive broad-spectrum antibiotics and various forms of organ support. Multidrug-resistant (MDR) organisms are a growing threat in all areas of medicine, but most markedly in the critically ill, where there is both loss...
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Series: | Case Reports in Infectious Diseases |
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doaj-09be61b234ac4887b1b7761a6fcb865b2020-11-25T03:08:27ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/84626598462659Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill PatientV. Ueckermann0E. Hoosien1N. De Villiers2J. Geldenhuys3Department Internal Medicine, University of Pretoria, Pretoria, South AfricaDepartment of Clinical Microbiology, Ampath National Reference Laboratory, Centurion, South AfricaGenetics Department, Ampath National Reference Laboratory, Centurion, South AfricaGenetics Department, Ampath National Reference Laboratory, Centurion, South AfricaDysbiosis of the microbiome is a common finding in critically ill patients, who receive broad-spectrum antibiotics and various forms of organ support. Multidrug-resistant (MDR) organisms are a growing threat in all areas of medicine, but most markedly in the critically ill, where there is both loss of host defences and widespread use of broad spectrum antibiotics. We present a case of a critically ill patient with persistent MDR Klebsiella pneumoniae infection, successfully treated with fecal microbiota transplantation (FMT), using stool of a rigorously-screened, healthy donor. FMT for Clostridium difficile colitis has been well described in the literature and is an established therapy for recurrent infections with Clostridium difficile. The use of FMT for other multidrug-resistant organisms is less frequently described, particularly in the context of critically ill patients. In our case, we have culture-documented clearance of the MDR Klebsiella pneumoniae form a patient of FMT.http://dx.doi.org/10.1155/2020/8462659 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
V. Ueckermann E. Hoosien N. De Villiers J. Geldenhuys |
spellingShingle |
V. Ueckermann E. Hoosien N. De Villiers J. Geldenhuys Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient Case Reports in Infectious Diseases |
author_facet |
V. Ueckermann E. Hoosien N. De Villiers J. Geldenhuys |
author_sort |
V. Ueckermann |
title |
Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient |
title_short |
Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient |
title_full |
Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient |
title_fullStr |
Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient |
title_full_unstemmed |
Fecal Microbial Transplantation for the Treatment of Persistent Multidrug-Resistant Klebsiella pneumoniae Infection in a Critically Ill Patient |
title_sort |
fecal microbial transplantation for the treatment of persistent multidrug-resistant klebsiella pneumoniae infection in a critically ill patient |
publisher |
Hindawi Limited |
series |
Case Reports in Infectious Diseases |
issn |
2090-6625 2090-6633 |
publishDate |
2020-01-01 |
description |
Dysbiosis of the microbiome is a common finding in critically ill patients, who receive broad-spectrum antibiotics and various forms of organ support. Multidrug-resistant (MDR) organisms are a growing threat in all areas of medicine, but most markedly in the critically ill, where there is both loss of host defences and widespread use of broad spectrum antibiotics. We present a case of a critically ill patient with persistent MDR Klebsiella pneumoniae infection, successfully treated with fecal microbiota transplantation (FMT), using stool of a rigorously-screened, healthy donor. FMT for Clostridium difficile colitis has been well described in the literature and is an established therapy for recurrent infections with Clostridium difficile. The use of FMT for other multidrug-resistant organisms is less frequently described, particularly in the context of critically ill patients. In our case, we have culture-documented clearance of the MDR Klebsiella pneumoniae form a patient of FMT. |
url |
http://dx.doi.org/10.1155/2020/8462659 |
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