Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception

Mapping the brain centers that mediate the sensory-perceptual processing of visceral afferent signals arising from the body (i.e., interoception) is useful both for characterizing normal brain activity and for understanding clinical disorders related to abnormal processing of visceral sensation. Her...

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Main Authors: Behnaz Jarrahi, Roger Gassert, Johann Wanek, Lars Michels, Ulrich Mehnert, Spyros S. Kollias
Format: Article
Language:English
Published: IEEE 2016-01-01
Series:IEEE Journal of Translational Engineering in Health and Medicine
Subjects:
Online Access:https://ieeexplore.ieee.org/document/7445138/
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spelling doaj-0a037a089724456f886c575b82b0646d2021-03-29T18:38:53ZengIEEEIEEE Journal of Translational Engineering in Health and Medicine2168-23722016-01-01411210.1109/JTEHM.2016.25382397445138Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of InteroceptionBehnaz Jarrahi0Roger Gassert1Johann Wanek2Lars Michels3Ulrich Mehnert4Spyros S. Kollias5Clinic for Neuroradiology, University Hospital Zurich, Zürich, SwitzerlandDepartment of Health Sciences and Technology, Institute of Robotics and Intelligent Systems, ETH Zurich, Zürich, SwitzerlandSpinal Cord Injury Center, Balgrist University Hospital, Zürich, SwitzerlandClinic for Neuroradiology, University Hospital Zurich, Zürich, SwitzerlandSpinal Cord Injury Center, Balgrist University Hospital, Zürich, SwitzerlandClinic for Neuroradiology, University Hospital Zurich, Zürich, SwitzerlandMapping the brain centers that mediate the sensory-perceptual processing of visceral afferent signals arising from the body (i.e., interoception) is useful both for characterizing normal brain activity and for understanding clinical disorders related to abnormal processing of visceral sensation. Here, we report a novel closed-system, electrohydrostatically driven master-slave device that was designed and constructed for delivering controlled fluidic stimulations of visceral organs and inner cavities of the human body within the confines of a 3T magnetic resonance imaging (MRI) scanner. The design concept and performance of the device in the MRI environment are described. In addition, the device was applied during a functional MRI (fMRI) investigation of visceral stimulation related to detrusor distention in two representative subjects to verify its feasibility in humans. System evaluation tests demonstrate that the device is MR-compatible with negligible impact on imaging quality [static signal-to-noise ratio (SNR) loss <;2.5% and temporal SNR loss <;3.5%], and has an accuracy of 99.68% for flow rate and 99.27% for volume delivery. A precise synchronization of the stimulus delivery with fMRI slice acquisition was achieved by programming the proposed device to detect the 5 V transistor-transistor logic (TTL) trigger signals generated by the MRI scanner. The fMRI data analysis using the general linear model analysis with the standard hemodynamic response function showed increased activations in the network of brain regions that included the insula, anterior and mid-cingulate and lateral prefrontal cortices, and thalamus in response to increased distension pressure on viscera. The translation from manually operated devices to an MR-compatible and MR-synchronized device under automatic control represents a useful innovation for clinical neuroimaging studies of human interoception.https://ieeexplore.ieee.org/document/7445138/MR-compatible sensors and actuatorsfMRIelectrohydrostatic actuationautomationvisceral afferent processing
collection DOAJ
language English
format Article
sources DOAJ
author Behnaz Jarrahi
Roger Gassert
Johann Wanek
Lars Michels
Ulrich Mehnert
Spyros S. Kollias
spellingShingle Behnaz Jarrahi
Roger Gassert
Johann Wanek
Lars Michels
Ulrich Mehnert
Spyros S. Kollias
Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
IEEE Journal of Translational Engineering in Health and Medicine
MR-compatible sensors and actuators
fMRI
electrohydrostatic actuation
automation
visceral afferent processing
author_facet Behnaz Jarrahi
Roger Gassert
Johann Wanek
Lars Michels
Ulrich Mehnert
Spyros S. Kollias
author_sort Behnaz Jarrahi
title Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
title_short Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
title_full Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
title_fullStr Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
title_full_unstemmed Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
title_sort design and application of a new automated fluidic visceral stimulation device for human fmri studies of interoception
publisher IEEE
series IEEE Journal of Translational Engineering in Health and Medicine
issn 2168-2372
publishDate 2016-01-01
description Mapping the brain centers that mediate the sensory-perceptual processing of visceral afferent signals arising from the body (i.e., interoception) is useful both for characterizing normal brain activity and for understanding clinical disorders related to abnormal processing of visceral sensation. Here, we report a novel closed-system, electrohydrostatically driven master-slave device that was designed and constructed for delivering controlled fluidic stimulations of visceral organs and inner cavities of the human body within the confines of a 3T magnetic resonance imaging (MRI) scanner. The design concept and performance of the device in the MRI environment are described. In addition, the device was applied during a functional MRI (fMRI) investigation of visceral stimulation related to detrusor distention in two representative subjects to verify its feasibility in humans. System evaluation tests demonstrate that the device is MR-compatible with negligible impact on imaging quality [static signal-to-noise ratio (SNR) loss <;2.5% and temporal SNR loss <;3.5%], and has an accuracy of 99.68% for flow rate and 99.27% for volume delivery. A precise synchronization of the stimulus delivery with fMRI slice acquisition was achieved by programming the proposed device to detect the 5 V transistor-transistor logic (TTL) trigger signals generated by the MRI scanner. The fMRI data analysis using the general linear model analysis with the standard hemodynamic response function showed increased activations in the network of brain regions that included the insula, anterior and mid-cingulate and lateral prefrontal cortices, and thalamus in response to increased distension pressure on viscera. The translation from manually operated devices to an MR-compatible and MR-synchronized device under automatic control represents a useful innovation for clinical neuroimaging studies of human interoception.
topic MR-compatible sensors and actuators
fMRI
electrohydrostatic actuation
automation
visceral afferent processing
url https://ieeexplore.ieee.org/document/7445138/
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