Subthalamic nucleus deep brain stimulation induces sustained neurorestoration in the mesolimbic dopaminergic system in a Parkinson's disease model

Subthalamic nucleus deep brain stimulation induces sustained neurorestoration in the mesolimbic dopaminergic system in a Parkinson's disease model

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapeutic principle in Parkinson's disease, but the underlying mechanisms, particularly mediating non-motor actions, remain largely enigmatic. Objective/hypothesis: The delayed onset of neuropsychiatri...

Full description

Bibliographic Details
Main Authors: Mareike Fauser, Manuel Ricken, Franz Markert, Nikolai Weis, Oliver Schmitt, Jan Gimsa, Christine Winter, Kathrin Badstübner-Meeske, Alexander Storch
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Disease
Subjects:
Deep brain stimulation
Subthalamic nucleus
Parkinson's disease
Ventral tegmental area
6-hydroxydopamine
Dopaminergic neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001534

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121001534

Similar Items