Cyclohexane, a potential drug of abuse with pernicious effects for the brain
Cyclohexane is a volatile solvent used as a harmless substitute for dangerous organic solvents in several products, such as paint thinners, gasoline and adhesives. Many of these products are used as drugs of abuse and can severely damage neural tissue and impair neurological functions. However, ther...
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00291/full |
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doaj-0b3b008184dd463186742732756309fc2020-11-24T23:47:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-01-01610.3389/fphar.2015.00291171396Cyclohexane, a potential drug of abuse with pernicious effects for the brainOscar eGonzalez-Perez0Tania eCampos-Ordonez1Universidad de ColimaUniversidad de ColimaCyclohexane is a volatile solvent used as a harmless substitute for dangerous organic solvents in several products, such as paint thinners, gasoline and adhesives. Many of these products are used as drugs of abuse and can severely damage neural tissue and impair neurological functions. However, there is very little information on the effects of cyclohexane on the brain. In humans, cyclohexane produces headaches, sleepiness, dizziness, limb weakness, motor changes and verbal memory impairment. Recent studies in mice have demonstrated behavioral alterations, reactive gliosis, microglial reactivity and oxidative stress in the brains of cyclohexane-exposed animals. This indicates that cyclohexane may represent a potential problem for public health. Therefore, studies are needed to clarify the neurobiological effects of this volatile compound, including the cellular and molecular mechanisms of neurotoxicity, and to minimize the human health risk posed by the intentional or accidental inhalation of this potential drug of abuse.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00291/fullInhalant AbuseMicrogliaOxidative StressTolueneNeurotoxicityastrocyte |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oscar eGonzalez-Perez Tania eCampos-Ordonez |
spellingShingle |
Oscar eGonzalez-Perez Tania eCampos-Ordonez Cyclohexane, a potential drug of abuse with pernicious effects for the brain Frontiers in Pharmacology Inhalant Abuse Microglia Oxidative Stress Toluene Neurotoxicity astrocyte |
author_facet |
Oscar eGonzalez-Perez Tania eCampos-Ordonez |
author_sort |
Oscar eGonzalez-Perez |
title |
Cyclohexane, a potential drug of abuse with pernicious effects for the brain |
title_short |
Cyclohexane, a potential drug of abuse with pernicious effects for the brain |
title_full |
Cyclohexane, a potential drug of abuse with pernicious effects for the brain |
title_fullStr |
Cyclohexane, a potential drug of abuse with pernicious effects for the brain |
title_full_unstemmed |
Cyclohexane, a potential drug of abuse with pernicious effects for the brain |
title_sort |
cyclohexane, a potential drug of abuse with pernicious effects for the brain |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2016-01-01 |
description |
Cyclohexane is a volatile solvent used as a harmless substitute for dangerous organic solvents in several products, such as paint thinners, gasoline and adhesives. Many of these products are used as drugs of abuse and can severely damage neural tissue and impair neurological functions. However, there is very little information on the effects of cyclohexane on the brain. In humans, cyclohexane produces headaches, sleepiness, dizziness, limb weakness, motor changes and verbal memory impairment. Recent studies in mice have demonstrated behavioral alterations, reactive gliosis, microglial reactivity and oxidative stress in the brains of cyclohexane-exposed animals. This indicates that cyclohexane may represent a potential problem for public health. Therefore, studies are needed to clarify the neurobiological effects of this volatile compound, including the cellular and molecular mechanisms of neurotoxicity, and to minimize the human health risk posed by the intentional or accidental inhalation of this potential drug of abuse. |
topic |
Inhalant Abuse Microglia Oxidative Stress Toluene Neurotoxicity astrocyte |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00291/full |
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