Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.

Persistence of transmitted HIV-1 drug resistance mutations associated with fitness costs and viral genetic backgrounds.

Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time. It is generally believed that differential TDRM-persistence is caused, at least pa...

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Bibliographic Details
Main Authors: Wan-Lin Yang, Roger D Kouyos, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Alexandra U Scherrer, Mohaned Shilaih, Trevor Hinkley, Christos Petropoulos, Sebastian Bonhoeffer, Huldrych F Günthard, Swiss HIV Cohort Study (SHCS)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4370492?pdf=render

Internet

http://europepmc.org/articles/PMC4370492?pdf=render

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