Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives
Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-...
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MDPI AG
2016-01-01
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| Series: | Applied Sciences |
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| Online Access: | http://www.mdpi.com/2076-3417/6/1/27 |
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doaj-0b74f1274fc844469cfdbd48a50ab9052020-11-24T21:15:21ZengMDPI AGApplied Sciences2076-34172016-01-01612710.3390/app6010027app6010027Alum as a Catalyst for the Synthesis of Bispyrazole DerivativesMohammad Ali Zolfigol0Ardeshir Khazaei1Fatemeh Karimitabar2Masoud Hamidi3Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, IranFaculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, IranFaculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, IranMedical Biotechnology Research Center, Guilan University of Medical Sciences, Rasht 4477166595, IranCompounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry.http://www.mdpi.com/2076-3417/6/1/27Alumbispyrazole derivatives3-methyl-1-phenyl-1H-pyrazol-5(4H)-oneCarbonyl compoundSolvent-free conditions |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mohammad Ali Zolfigol Ardeshir Khazaei Fatemeh Karimitabar Masoud Hamidi |
| spellingShingle |
Mohammad Ali Zolfigol Ardeshir Khazaei Fatemeh Karimitabar Masoud Hamidi Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives Applied Sciences Alum bispyrazole derivatives 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one Carbonyl compound Solvent-free conditions |
| author_facet |
Mohammad Ali Zolfigol Ardeshir Khazaei Fatemeh Karimitabar Masoud Hamidi |
| author_sort |
Mohammad Ali Zolfigol |
| title |
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives |
| title_short |
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives |
| title_full |
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives |
| title_fullStr |
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives |
| title_full_unstemmed |
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives |
| title_sort |
alum as a catalyst for the synthesis of bispyrazole derivatives |
| publisher |
MDPI AG |
| series |
Applied Sciences |
| issn |
2076-3417 |
| publishDate |
2016-01-01 |
| description |
Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry. |
| topic |
Alum bispyrazole derivatives 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one Carbonyl compound Solvent-free conditions |
| url |
http://www.mdpi.com/2076-3417/6/1/27 |
| work_keys_str_mv |
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