Different pattern of the second outbreak of COVID-19 in Marseille, France
Objective: To describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods. Methods: Demographics, hospitalization rate, transfer to intensive care unit (ICU)...
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Format: | Article |
Language: | English |
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Elsevier
2021-01-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220322086 |
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doaj-0b772a839dc04d5d87db9d66ca0d8976 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philippe Gautret Philippe Colson Jean Christophe Lagier Laurence Camoin-Jau Audrey Giraud-Gatineau Sophia Boudjema Julie Finance Hervé Chaudet Didier Raoult |
spellingShingle |
Philippe Gautret Philippe Colson Jean Christophe Lagier Laurence Camoin-Jau Audrey Giraud-Gatineau Sophia Boudjema Julie Finance Hervé Chaudet Didier Raoult Different pattern of the second outbreak of COVID-19 in Marseille, France International Journal of Infectious Diseases COVID-19 Seasonality Severity markers Lethality |
author_facet |
Philippe Gautret Philippe Colson Jean Christophe Lagier Laurence Camoin-Jau Audrey Giraud-Gatineau Sophia Boudjema Julie Finance Hervé Chaudet Didier Raoult |
author_sort |
Philippe Gautret |
title |
Different pattern of the second outbreak of COVID-19 in Marseille, France |
title_short |
Different pattern of the second outbreak of COVID-19 in Marseille, France |
title_full |
Different pattern of the second outbreak of COVID-19 in Marseille, France |
title_fullStr |
Different pattern of the second outbreak of COVID-19 in Marseille, France |
title_full_unstemmed |
Different pattern of the second outbreak of COVID-19 in Marseille, France |
title_sort |
different pattern of the second outbreak of covid-19 in marseille, france |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-01-01 |
description |
Objective: To describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods. Methods: Demographics, hospitalization rate, transfer to intensive care unit (ICU), lethality, clinical and biological parameters were investigated. Results: Compared to those seen in March-April, COVID-19 patients seen in June-August were significantly younger (39.2 vs. 45.3 years), more likely to be male (52.9% vs. 45.6%), and less likely to be hospitalized (10.7 vs. 18.0%), to be transferred to ICU (0.9% vs. 1.8%) and to die (0.1% vs. 1.1%). Their mean fibrinogen and D-dimer blood levels were lower (1.0 vs. 1.5 g/L and 0.6 vs. 1.1 μg/mL, respectively). By contrast, their viral load was higher (cycle threshold ≤16 = 5.1% vs. 3.7%). Conclusions: Patients in the two periods did not present marked age and sex differences, but markers of severity were undoubtedly less prevalent in the summer period, associating with a 10 times decrease in the lethality rate. |
topic |
COVID-19 Seasonality Severity markers Lethality |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220322086 |
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AT philippegautret differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT philippecolson differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT jeanchristophelagier differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT laurencecamoinjau differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT audreygiraudgatineau differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT sophiaboudjema differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT juliefinance differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT hervechaudet differentpatternofthesecondoutbreakofcovid19inmarseillefrance AT didierraoult differentpatternofthesecondoutbreakofcovid19inmarseillefrance |
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doaj-0b772a839dc04d5d87db9d66ca0d89762020-12-27T04:28:17ZengElsevierInternational Journal of Infectious Diseases1201-97122021-01-011021719Different pattern of the second outbreak of COVID-19 in Marseille, FrancePhilippe Gautret0Philippe Colson1Jean Christophe Lagier2Laurence Camoin-Jau3Audrey Giraud-Gatineau4Sophia Boudjema5Julie Finance6Hervé Chaudet7Didier Raoult8IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, France; Laboratoire d'Hématologie, Hôpital de la Timone, APHM, boulevard Jean- Moulin, 13005 Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, France; Assistance Publique de Marseille, Explorations Fonctionnelles Respiratoires, Aix Marseille Université, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, FranceIHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), 27 boulevard Jean Moulin, 13005 Marseille, France; Corresponding author at: IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France.Objective: To describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods. Methods: Demographics, hospitalization rate, transfer to intensive care unit (ICU), lethality, clinical and biological parameters were investigated. Results: Compared to those seen in March-April, COVID-19 patients seen in June-August were significantly younger (39.2 vs. 45.3 years), more likely to be male (52.9% vs. 45.6%), and less likely to be hospitalized (10.7 vs. 18.0%), to be transferred to ICU (0.9% vs. 1.8%) and to die (0.1% vs. 1.1%). Their mean fibrinogen and D-dimer blood levels were lower (1.0 vs. 1.5 g/L and 0.6 vs. 1.1 μg/mL, respectively). By contrast, their viral load was higher (cycle threshold ≤16 = 5.1% vs. 3.7%). Conclusions: Patients in the two periods did not present marked age and sex differences, but markers of severity were undoubtedly less prevalent in the summer period, associating with a 10 times decrease in the lethality rate.http://www.sciencedirect.com/science/article/pii/S1201971220322086COVID-19SeasonalitySeverity markersLethality |